Characterization of Adverse Reactions to Antihypertensive Drugs

Authors

Keywords:

Antihypertensive Agents, Metabolic Side Effects of Drugs and Substances, Drug-Related Side Effects and Adverse Reactions, Pharmaceutical Preparations

Abstract

Introduction: Cardiovascular diseases are the most frequent cause of morbidity and mortality and although their control is possible with pharmacotherapy, this is not exempt from causing adverse reactions.

Objective: To characterize adverse reactions to antihypertensive medications.

Methods: An observational, descriptive, cross-sectional study was carried out.The universe consisted of 1,711 records in the time period from 2019-2020, the sample was of 127 patients who reported symptoms related to the use of antihypertensive medications, these were registered in the Provincial Pharmacovigilance Coordinating Unit.

Results: Symptoms predominated in the age of 62 years and older with 32.28%, the female sex 66.14% and the respiratory organ system 36.21%. In the case of frequency, causality and severity, it corresponded to frequent with 62.99%, mild with 55.12% and probable with 70.86%. The most reported medication was captopril 37% and the most frequent symptom was cough with 35.43%.

Conclusions: There may be underreporting of adverse reactions to antihypertensives; it is necessary to establish strategies for their identification. The female sex predominates, aged 62 years and older, the most common pharmacological group is angiotensin-converting enzyme inhibitors, the most used medication is captopril, the respiratory system and cough are the prevailing symptoms.

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References

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2024-05-24 — Updated on 2024-07-13

How to Cite

1.
Benítez-Rojas L de la C, Cruz Rodríguez RA, Ibert Muñoz C, Castro Querol O, Rojas Pérez S de la C. Characterization of Adverse Reactions to Antihypertensive Drugs. Columna med. [Internet]. 2024 Jul. 13 [cited 2024 Sep. 29];3(1):e185. Available from: https://revcolumnamedica.sld.cu/index.php/columnamedica/article/view/185

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Vol. 3 (2024): (Continuous Publication)

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