Characterization of Adverse Reactions to Antihypertensive Drugs
Keywords:
Antihypertensive Agents, Metabolic Side Effects of Drugs and Substances, Drug-Related Side Effects and Adverse Reactions, Pharmaceutical PreparationsAbstract
Introduction: Cardiovascular diseases are the most frequent cause of morbidity and mortality and although their control is possible with pharmacotherapy, this is not exempt from causing adverse reactions.
Objective: To characterize adverse reactions to antihypertensive medications.
Methods: An observational, descriptive, cross-sectional study was carried out.The universe consisted of 1,711 records in the time period from 2019-2020, the sample was of 127 patients who reported symptoms related to the use of antihypertensive medications, these were registered in the Provincial Pharmacovigilance Coordinating Unit.
Results: Symptoms predominated in the age of 62 years and older with 32.28%, the female sex 66.14% and the respiratory organ system 36.21%. In the case of frequency, causality and severity, it corresponded to frequent with 62.99%, mild with 55.12% and probable with 70.86%. The most reported medication was captopril 37% and the most frequent symptom was cough with 35.43%.
Conclusions: There may be underreporting of adverse reactions to antihypertensives; it is necessary to establish strategies for their identification. The female sex predominates, aged 62 years and older, the most common pharmacological group is angiotensin-converting enzyme inhibitors, the most used medication is captopril, the respiratory system and cough are the prevailing symptoms.
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